Danon Y L, Dinari G, Garty B Z, Horodniceanu C, Nitzan M, Grunebaum M
J Pediatr Gastroenterol Nutr. 1983 Nov;2(4):663-6. doi: 10.1097/00005176-198311000-00016.
In view of the role of immunoglobulin A (IgA) in the local host defenses of the gut and biliary tract, and the association of IgA deficiency with various intestinal disorders, an ultrasonographic study was performed to determine the prevalence of gallstones in selective IgA deficiency. Eight of 13 children (three girls and five boys) with selective IgA deficiency had abnormal biliary sonograms. Four had cholelithiasis, and four had biliary sludge only. IgA deficiency may predispose to gallbladder infection, and thus to the development of gallstones. Decreased bile acid pool due to intestinal losses, and biliary stasis due to reduced hormonal gallbladder stimulation may also play a role in some cases, but further studies are needed. This association adds a new gastrointestinal abnormality to those known to be associated with selective IgA deficiency.
鉴于免疫球蛋白A（IgA）在肠道和胆道局部宿主防御中的作用，以及IgA缺乏与各种肠道疾病的关联，我们进行了一项超声检查研究，以确定选择性IgA缺乏症患者胆结石的患病率。13名选择性IgA缺乏症儿童（3名女孩和5名男孩）中有8名胆道超声检查结果异常。4名患有胆结石，4名仅有胆泥。IgA缺乏可能易导致胆囊感染，进而引发胆结石。在某些情况下，因肠道丢失导致胆汁酸池减少以及因激素对胆囊刺激减少导致胆汁淤积也可能起作用，但还需要进一步研究。这种关联为已知与选择性IgA缺乏相关的胃肠道异常增加了一种新的情况。
