Nagasaka M, Kameyama T
J Pharmacobiodyn. 1983 Aug;6(8):523-6. doi: 10.1248/bpb1978.6.523.
Mice exhibited a marked suppression of motor activity when placed into the same environment in which they had previously received electric foot shocks. Apomorphine-HCl (0.1 - 10 mg/kg) produced a dose-dependent reduction of the conditioned suppression of activity, but did not increase activity in non-shocked mice. Diazepam (0.2, 1, and 5 mg/kg), meprobamate (25 and 50 mg/kg), and chlorpromazine-HCl (2 and 5 mg/kg) did not reduce conditioned suppression. Thus, the conditioned suppression caused by a quick conditioning technique does not produce similar results to those using the conditioned emotional response involving suppression of operant lever-pressing behavior.
当被放置在先前接受过足部电击的相同环境中时，小鼠表现出明显的运动活动抑制。盐酸阿扑吗啡（0.1 - 10毫克/千克）可使条件性活动抑制呈剂量依赖性降低，但不会增加未受电击小鼠的活动。地西泮（0.2、1和5毫克/千克）、甲丙氨酯（25和50毫克/千克）以及盐酸氯丙嗪（2和5毫克/千克）均未降低条件性抑制。因此，快速条件化技术引起的条件性抑制与使用涉及抑制操作性杠杆按压行为的条件性情绪反应所产生的结果不同。
