Kameyama T, Nagasaka M
Pharmacol Biochem Behav. 1982 Jul;17(1):59-63. doi: 10.1016/0091-3057(82)90263-5.
Electric shock experienced rats exhibited a marked suppression of motor activity when placed in the same environment in which the animal received shocks. At 24 hr after electrical shocks, the shock frequencies of 1/10 Hz to 1/180 Hz equally produced a marked suppression of motility. However, electric shock experienced rats exhibited a similar degree of locomotor activity that was seen with the non-shocked rats, when the motility of the animals was measured by using Animex system at 24 hr after electrical shocks. Therefore, this suppression of motility was found to be a consistent response and to be a conditioned response to the environment. Diazepam (1.2.5 or 5 mg/kg, IP) did not show any effect on the conditioned suppression. Apomorphine-HCl (0.1, 0.5 or 1 mg/kg, IP) caused attenuation of the conditioned suppression in relation to dose, but did not increase motor activity of the non-shocked rats. Thus, conditioned suppression caused by a quick conditioning technique may not be associated with anxiety.
遭受电击的大鼠被置于其遭受电击的相同环境中时，会表现出明显的运动活动抑制。在电击后24小时，1/10赫兹至1/180赫兹的电击频率均会同样导致明显的运动抑制。然而，当在电击后24小时使用Animex系统测量动物的运动能力时，遭受电击的大鼠表现出与未遭受电击的大鼠相似程度的运动活动。因此，这种运动抑制被发现是一种一致的反应，并且是对环境的条件反应。地西泮（1.2、5或5毫克/千克，腹腔注射）对条件性抑制没有任何影响。盐酸阿扑吗啡（0.1、0.5或1毫克/千克，腹腔注射）会根据剂量导致条件性抑制减弱，但不会增加未遭受电击的大鼠的运动活动。因此，快速条件化技术引起的条件性抑制可能与焦虑无关。
