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[维生素D供应不同的大鼠骨组织中可溶性胶原蛋白组分的α、β和γ链的相对含量]

[Relative content of the alpha-, beta- and gamma-chains of the soluble collagen fractions from the bone tissue of rats with a varying supply of vitamin D].

作者信息

Isaeva V A, Spirichev V B

出版信息

Vopr Med Khim. 1978 Mar-Apr;24(2):270-4.

PMID:664454
Abstract

Insufficiency of vitamin D caused a decrease in content of salt- and acid soluble collagen fractions with simultaneous increase of insoluble its fraction in epiphyses of rat tubular bones. At the same time relative content of monomeric alpha-chains was decreased but content of dimeric (beta-chains) and trimeric (gamma-chains) subunits was increased in both collagen fractions. These data are in good agreement with assumption on the increased growth of bone collagen under insufficiency of vitamin D.

摘要

维生素D缺乏导致大鼠管状骨骨骺中盐溶性和酸溶性胶原蛋白组分含量降低,同时不溶性胶原蛋白组分增加。与此同时,在两种胶原蛋白组分中,单体α链的相对含量降低,但二聚体(β链)和三聚体(γ链)亚基的含量增加。这些数据与维生素D缺乏时骨胶原蛋白生长增加的假设高度一致。

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