Karol M D, Veng-Pedersen P, Brashear R E
J Pharmacokinet Biopharm. 1983 Jun;11(3):273-87. doi: 10.1007/BF01061868.
Two possible schemes describing the transfer of theophylline across the blood-brain barrier are investigated. The first, the "diffusion only model," assumes that the rate of transfer is proportional to the difference in free drug concentration in the serum and cerebrospinal fluid. The second, the "diffusion and flow model," has the added feature that drug may be transferred from the CSF to the blood by the continuous secretion of CSF into the blood. Comparison of the results of nonlinear regression for the two proposed schemes indicated that the "diffusion and flow" model best describes the transfer process. The analysis indicates that the parameters obtained for the "diffusion and flow" model are physiologically meaningful.
研究了两种描述茶碱通过血脑屏障转运的可能方案。第一种是“仅扩散模型”，假定转运速率与血清和脑脊液中游离药物浓度的差值成正比。第二种是“扩散与流动模型”，其额外的特点是药物可通过脑脊液持续分泌入血而从脑脊液转运至血液。对这两种提出的方案进行非线性回归结果比较表明，“扩散与流动”模型最能描述转运过程。分析表明，从“扩散与流动”模型获得的参数具有生理意义。
