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一般乳头状房室系统速率常数的上下限。

The upper and lower bounds of rate constants for general mammillary compartment systems.

作者信息

Lam C F, Chung A

出版信息

J Pharmacokinet Biopharm. 1983 Jun;11(3):289-301. doi: 10.1007/BF01061869.

DOI:10.1007/BF01061869
PMID:6644554
Abstract

The upper and lower bounds of rate constants for general mammillary three and four compartment systems have been derived. It is further proposed that the midpoints of the bounds can be used as initial estimates for parameter estimation. Numerical examples are given demonstrating the closeness of the calculated midpoints to the "known" rate constants of both the three and four compartment systems.

摘要

已推导出一般乳突状三室和四室系统速率常数的上下界。还进一步提出，这些界的中点可作为参数估计的初始估计值。给出了数值示例，证明了计算出的中点与三室和四室系统“已知”速率常数的接近程度。

相似文献

1
The upper and lower bounds of rate constants for general mammillary compartment systems.一般乳头状房室系统速率常数的上下限。
J Pharmacokinet Biopharm. 1983 Jun;11(3):289-301. doi: 10.1007/BF01061869.
2
A four compartment linear mammillary model.四房室线性乳头体模型。
Int J Biomed Comput. 1987 Jan;20(1-2):27-33. doi: 10.1016/0020-7101(87)90011-0.
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General pharmacokinetic equations for linear mammillary models with drug absorption into peripheral compartments.具有药物吸收进入外周室的线性乳头状模型的一般药代动力学方程。
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Identifiability and interval identifiability of mammillary and catenary compartmental models with some known rate constants.具有一些已知速率常数的乳头状和悬链状房室模型的可识别性和区间可识别性。
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An incremental method for the study of the absorption of drugs whose kinetics are described by a two-compartment model: estimation of the microscopic rate constants.
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General treatment of linear mammillary models.
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本文引用的文献

1
Volume terms in pharmacokinetics.药代动力学中的容积术语。
J Pharm Sci. 1969 May;58(5):639-41. doi: 10.1002/jps.2600580534.
2
General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics.线性乳突模型的一般处理方法，即如药代动力学中所使用的那样，从任何隔室中消除。
J Pharm Sci. 1972 Apr;61(4):536-41. doi: 10.1002/jps.2600610408.
3
Curve fitting and modeling in pharmacokinetics and some practical experiences with NONLIN and a new program FUNFIT.药代动力学中的曲线拟合与建模以及使用NONLIN和新程序FUNFIT的一些实践经验。
J Pharmacokinet Biopharm. 1977 Oct;5(5):513-31. doi: 10.1007/BF01061732.
4
Linear pharmacokinetic models: geometric construction to determine transfer and elimination rate constants.线性药代动力学模型：用于确定转运和消除速率常数的几何学构建方法。
J Pharmacokinet Biopharm. 1977 Apr;5(2):147-59. doi: 10.1007/BF01066218.