一般乳头状房室系统速率常数的上下限。

The upper and lower bounds of rate constants for general mammillary compartment systems.

作者信息

Lam C F, Chung A

出版信息

J Pharmacokinet Biopharm. 1983 Jun;11(3):289-301. doi: 10.1007/BF01061869.

Abstract

The upper and lower bounds of rate constants for general mammillary three and four compartment systems have been derived. It is further proposed that the midpoints of the bounds can be used as initial estimates for parameter estimation. Numerical examples are given demonstrating the closeness of the calculated midpoints to the "known" rate constants of both the three and four compartment systems.

摘要

已推导出一般乳突状三室和四室系统速率常数的上下界。还进一步提出，这些界的中点可作为参数估计的初始估计值。给出了数值示例，证明了计算出的中点与三室和四室系统“已知”速率常数的接近程度。