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具有药物吸收进入外周室的线性乳头状模型的一般药代动力学方程。

General pharmacokinetic equations for linear mammillary models with drug absorption into peripheral compartments.

作者信息

Vaughan D P, Mallard D J, Trainor A, Mitchard M

出版信息

Eur J Clin Pharmacol. 1975 Feb 28;8(2):141-8. doi: 10.1007/BF00561564.

DOI:10.1007/BF00561564
PMID:1233210
Abstract

General equations are derived for the disposition functions of any compartment in a linear mammillary model, when the system input occurs into a peripheral compartment. Laplace transforms and matrix algebra are used to derive these equations. Equations describing the time-course of a drug in any compartment are readily obtainable using disposition and input functions.

摘要

当系统输入发生在外周室时，推导了线性乳突模型中任何室的处置函数的通用方程。使用拉普拉斯变换和矩阵代数来推导这些方程。利用处置函数和输入函数，可以很容易地得到描述药物在任何室中的时间进程的方程。

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本文引用的文献

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ON SOME TOPOLOGICAL PROPERTIES OF THE SYSTEMS OF COMPARTMENTS.关于隔室系统的一些拓扑性质
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Some pharmacokinetic aspects of 5-(dimethylriazeno)-imidazole-4-carboxamide in the dog.5-（二甲基三氮烯基）-咪唑-4-甲酰胺在犬体内的一些药代动力学方面
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Pharmacokinetic basis for the influence of route of administration on the area under the plasma concentration-time curve.给药途径对血浆浓度-时间曲线下面积影响的药代动力学基础。
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General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics.线性乳突模型的一般处理方法，即如药代动力学中所使用的那样，从任何隔室中消除。
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Pharmacokinetics of trichloroethanol and metabolites and interconversions among variously referenced pharmacokinetic parameters.三氯乙醇及其代谢产物的药代动力学以及各种引用的药代动力学参数之间的相互转化。
J Pharm Sci. 1973 Apr;62(4):550-72. doi: 10.1002/jps.2600620404.
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Pharmacokinetics of absorption, distribution and elimination of fenfluramine and its main metabolite in man.
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Comparative pharmacokinetics of coumarin anticoagulants. IV. Application of a three-compartmental model to the analysis of the dose-dependent kinetics of bishydroxycoumarin elimination.香豆素类抗凝剂的比较药代动力学。IV. 三室模型在双香豆素消除剂量依赖性动力学分析中的应用。
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