使用高效液相色谱法和高效薄层色谱法对多塞平和去甲多塞平进行的比较测定。
Comparative assays for doxepin and desmethyldoxepin using high-performance liquid chromatography and high-performance thin-layer chromatography.
作者信息
Faulkner R D, Lee C
出版信息
J Pharm Sci. 1983 Oct;72(10):1165-7. doi: 10.1002/jps.2600721014.
Two chromatographic methods, high-performance liquid chromatography (HPLC) and high-performance thin-layer chromatography (HPTLC) were compared for sensitivity and reproducibility in the analysis of the tricyclic antidepressant doxepin and its metabolite, desmethyldoxepin, in plasma. The HPLC procedure yielded a better reproducibility, as reflected by the coefficient of variation, and a higher sensitivity, as reflected by the minimum detectable quantity. The application of these methods for therapeutic and subtherapeutic monitoring of plasma levels of the drug is described.
比较了两种色谱方法，即高效液相色谱法（HPLC）和高效薄层色谱法（HPTLC），用于分析血浆中三环类抗抑郁药多塞平和其代谢物去甲多塞平的灵敏度和重现性。高效液相色谱法的变异系数表明其重现性更好，最小检测量表明其灵敏度更高。描述了这些方法在该药物血浆水平治疗和亚治疗监测中的应用。
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