生物等效性评估的贝叶斯方法：一个实例

Bayesian approach to bioequivalence assessment: an example.

作者信息

Fluehler H, Grieve A P, Mandallaz D, Mau J, Moser H A

出版信息

J Pharm Sci. 1983 Oct;72(10):1178-81. doi: 10.1002/jps.2600721018.

Abstract

The statistical methods required for a Bayesian analysis of bioequivalence are outlined and numerically illustrated. The analysis consists of the calculation of the posterior probability, given the experimental results, that the ratio of true means of a new and a standard formulation of a drug with respect to some biological response lies in a given interval. Nomograms helpful for the calculation of these probabilities are provided.

摘要

概述并通过数值示例说明了贝叶斯生物等效性分析所需的统计方法。该分析包括在给定实验结果的情况下，计算一种药物新制剂与标准制剂关于某种生物学反应的真实均值之比落在给定区间内的后验概率。提供了有助于计算这些概率的列线图。