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用于眼科制剂中萘甲唑啉和四氢唑啉的高效液相色谱稳定性指示测定法。

High-performance liquid chromatographic stability-indicating assay for naphazoline and tetrahydrozoline in ophthalmic preparations.

作者信息

Bauer J, Krogh S

出版信息

J Pharm Sci. 1983 Nov;72(11):1347-9. doi: 10.1002/jps.2600721128.

DOI:10.1002/jps.2600721128
PMID:6644602
Abstract

A high-performance liquid chromatographic (HPLC) analysis for tetrahydrozoline and naphazoline in ophthalmic solutions is presented. The analysis allows a more reproducible, direct stability-indicating assay than the colorimetric methods generally employed. The HPLC system is so designed that a variety of ophthalmic solutions containing either naphazoline or tetrahydrozoline can be analyzed concomitantly.

摘要

本文介绍了一种用于眼科溶液中四氢唑啉和萘甲唑啉的高效液相色谱（HPLC）分析方法。与通常采用的比色法相比，该分析方法能提供更具重现性的直接稳定性指示测定。所设计的HPLC系统能够同时分析多种含有萘甲唑啉或四氢唑啉的眼科溶液。

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