Hsu Y R, Norton S J
J Med Chem. 1983 Dec;26(12):1784-5. doi: 10.1021/jm00366a027.
An effective competitive inhibitor of mammalian glyoxalase II has been synthesized and studied. The compound, S-carbobenzoxyglutathione, is almost totally inactive as an inhibitor of mammalian glyoxalase I. This is in marked contrast to other glyoxalase II competitive inhibitors, which in general are even more effective against glyoxalase I. S-Carbobenzoxyglutathione has found utility as an affinity ligand for the purification of rat liver glyoxalase II, and it may well have use in the study of the glyoxalase enzymes in vivo.
一种有效的哺乳动物乙二醛酶II竞争性抑制剂已被合成并进行了研究。该化合物，S-苄氧羰基谷胱甘肽，作为哺乳动物乙二醛酶I的抑制剂几乎完全没有活性。这与其他乙二醛酶II竞争性抑制剂形成了显著对比，其他抑制剂通常对乙二醛酶I更有效。S-苄氧羰基谷胱甘肽已被用作纯化大鼠肝脏乙二醛酶II的亲和配体，并且很可能在体内乙二醛酶的研究中有用途。
