McCall J M, Aiken J W, Chidester C G, DuCharme D W, Wendling M G
J Med Chem. 1983 Dec;26(12):1791-3. doi: 10.1021/jm00366a030.
Di- and triaminopyrimidine 3-oxides (e.g., 2,4-diamino-6-piperidinylpyrimidine 3-oxide and 2,4-diamino-6-(diallylamino)triazine 3-oxide) react with sources of sulfur trioxide, such as sulfur trioxide trimethylamine or chlorosulfuryl chloride, to yield the corresponding heterocyclic O-sulfates. These sulfates are inner salts with unusual physical properties. The structure of the O-sulfate of 2,4-diamino-6-piperidinylpyrimidine 3-oxide was confirmed by X-ray. These O-sulfates are hypotensives. They apparently act by direct vasodilation.
二氨基和三氨基嘧啶3-氧化物（例如，2,4-二氨基-6-哌啶基嘧啶3-氧化物和2,4-二氨基-6-（二烯丙基氨基）三嗪3-氧化物）与三氧化硫源，如三氧化硫三甲胺或氯磺酰氯反应，生成相应的杂环O-硫酸盐。这些硫酸盐是具有不寻常物理性质的内盐。2,4-二氨基-6-哌啶基嘧啶3-氧化物的O-硫酸盐结构通过X射线得到证实。这些O-硫酸盐是降压药。它们显然通过直接血管舒张起作用。
