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Topical agents and erectile dysfunction: is there a place?

作者信息

Yap Ronald L, McVary Kevin T

机构信息

Department of Urology, Northwestern University Medical School, Tarry 11-725, 303 East Chicago Avenue, Chicago, IL 60611, USA.

出版信息

Curr Urol Rep. 2002 Dec;3(6):471-6. doi: 10.1007/s11934-002-0100-x.

DOI:10.1007/s11934-002-0100-x
PMID:12425870
Abstract

Despite the proven efficacy of oral therapy for erectile dysfunction (ED), some patients are unable to take these medications because of drug interactions (ie, sildenafil and nitroglycerin) or a lack of response. Topical agents represent another minimally invasive option for the treatment of ED. This review discusses the impediments to effective topical therapy and examines the developmental status of several candidate drugs. Although still in the investigative stage, topical medications can be another tool in the urologist's armamentarium against ED.

摘要

相似文献

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Topical agents and erectile dysfunction: is there a place?
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2
Scoping review exploring advancements in topical agent therapies for erectile dysfunction.探讨局部药物治疗勃起功能障碍的进展范围综述。
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Intracavernosal injection therapy. Does it still have a role in erectile dysfunction?海绵体内注射疗法。它在勃起功能障碍治疗中仍有作用吗?
Aust Fam Physician. 2001 Jan;30(1):43-6.
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[Topical treatment of erectile dysfunction. Possibilities and perspectives].[勃起功能障碍的局部治疗。可能性与前景]
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Pharmacotherapy for erectile dysfunction.勃起功能障碍的药物治疗。
Chin Med J (Engl). 2000 Apr;113(4):291-8.
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Our experience with pharmacological erection treatment of erectile dysfunction.我们在勃起功能障碍药物治疗方面的经验。
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Developmental status of topical therapies for erectile and ejaculatory dysfunction.勃起功能障碍和射精功能障碍局部治疗的发展现状。
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Combination therapy using oral alpha-blockers and intracavernosal injection in men with erectile dysfunction.口服α受体阻滞剂与海绵体内注射联合治疗男性勃起功能障碍。
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Papaverine hydrochloride containing nanostructured lyotropic liquid crystal formulation as a potential drug delivery system for the treatment of erectile dysfunction.含盐酸罂粟碱的纳米结构溶致液晶制剂作为治疗勃起功能障碍的潜在药物递送系统。
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Pharmacotherapy of sexual dysfunctions : current status.

本文引用的文献

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Topical alprostadil in the treatment of Female Sexual Arousal Disorder: a pilot study.
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Pilot study of the transdermal application of testosterone gel to the penile skin for the treatment of hypogonadotropic men with erectile dysfunction.
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A double-blind, placebo-controlled, efficacy and safety study of topical gel formulation of 1% alprostadil (Topiglan) for the in-office treatment of erectile dysfunction.一项关于1%前列地尔局部凝胶制剂(Topiglan)用于门诊治疗勃起功能障碍的双盲、安慰剂对照的疗效和安全性研究。
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Nanoparticles as a novel delivery vehicle for therapeutics targeting erectile dysfunction.纳米颗粒作为一种新型治疗药物载体,靶向治疗勃起功能障碍。
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4
Developmental status of topical therapies for erectile and ejaculatory dysfunction.勃起功能障碍和射精功能障碍局部治疗的发展现状。
Int J Impot Res. 2000 Oct;12 Suppl 4:S80-5. doi: 10.1038/sj.ijir.3900583.
5
Testosterone supplementation for erectile dysfunction: results of a meta-analysis.睾酮补充治疗勃起功能障碍:一项荟萃分析的结果
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6
Prostaglandin E1 activates the large-conductance KCa channel in human corporal smooth muscle cells.
Int J Impot Res. 1999 Aug;11(4):189-99. doi: 10.1038/sj.ijir.3900399.
7
Topical prostaglandin E1 SEPA gel for the treatment of erectile dysfunction.用于治疗勃起功能障碍的局部用前列腺素E1 SEPA凝胶
J Urol. 1999 Sep;162(3 Pt 1):726-30; discussion 730-1. doi: 10.1097/00005392-199909010-00025.
8
Transcutaneous nitroglycerine in the treatment of erectile dysfunction: a placebo controlled clinical trial.经皮硝酸甘油治疗勃起功能障碍:一项安慰剂对照临床试验。
Int J Impot Res. 1999 Feb;11(1):35-9. doi: 10.1038/sj.ijir.3900380.
9
Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group.口服西地那非治疗勃起功能障碍。西地那非研究小组。
N Engl J Med. 1998 May 14;338(20):1397-404. doi: 10.1056/NEJM199805143382001.
10
Treatment of men with erectile dysfunction with transurethral alprostadil. Medicated Urethral System for Erection (MUSE) Study Group.经尿道前列地尔治疗男性勃起功能障碍。勃起用药尿道系统(MUSE)研究组。
N Engl J Med. 1997 Jan 2;336(1):1-7. doi: 10.1056/NEJM199701023360101.