Maes A, Staessen C, Hens L, Vamos E, Kirsch-Volders M, Lauwers M C, Defrise-Gussenhoven E, Susanne C
J Med Genet. 1983 Oct;20(5):350-6. doi: 10.1136/jmg.20.5.350.
The possible influence of the high polymorphic C heterochromatic regions of human chromosomes 1, 9, 16, and Y on meiotic chromosome segregation was investigated. Faulty chromosome segregation may be the result of either an abnormal quantity of C heterochromatin on the homologues, or disequilibrium between the homologues. The aim of our study was to determine whether either a variation in the amounts of total C heterochromatin or differences in the amounts of C heterochromatin between homologues could lead to faulty chromosome segregation. The study was performed on C banded metaphases obtained from peripheral lymphocyte cultures of 15 couples with recurrent early abortions and 15 control couples, all Caucasians. Analysis of variance was first performed on separate metaphases to measure intra-individual, inter-individual, and between population variation in a hierarchical model. Since the significant intra-individual differences covered the other parameters we performed, secondly, a one way analysis of variance on the mean values of metaphases per person in order to measure the inter-individual and between population variation. The results did not show a relationship between C heterochromatin lengths and occurrence of recurrent abortions.
研究了人类1号、9号、16号和Y染色体的高度多态性C异染色质区域对减数分裂染色体分离的可能影响。染色体分离异常可能是同源染色体上C异染色质数量异常，或者同源染色体之间不平衡的结果。我们研究的目的是确定总C异染色质数量的变化或同源染色体之间C异染色质数量的差异是否会导致染色体分离异常。该研究对15对有反复早期流产史的夫妇和15对对照夫妇（均为白种人）外周血淋巴细胞培养获得的C带中期相进行。首先在单独的中期相上进行方差分析，以测量分层模型中的个体内、个体间和群体间变异。由于显著的个体内差异涵盖了我们进行的其他参数，其次，对每人中期相的平均值进行单因素方差分析，以测量个体间和群体间变异。结果未显示C异染色质长度与反复流产发生率之间存在关联。
