Topley J M, Cupidore L, Vaidya S, Hayes R J, Serjeant G R
J Pediatr. 1982 Aug;101(2):176-9. doi: 10.1016/s0022-3476(82)80112-1.
The pattern of infection was compared in 139 children with sickle cell-hemoglobin C (SC) disease and in 250 control children with a normal hemoglobin (AA) genotype ascertained at birth and followed prospectively for periods of zero to six years. Both infection incidence rates and survival curve analysis indicated highly significant increases in serious infection among children with SC disease. Respiratory infection and gastroenteritis were the most common infections, but only respiratory infections were significantly more frequent in SC disease. Pneumococcal bacteremia was confined to the SC group. No hematologic differences were apparent between SC patients with and without a history of serious infection, but infection was significantly more common in patients manifesting early splenomegaly.
对139名镰状细胞-血红蛋白C（SC）病患儿和250名出生时确定为正常血红蛋白（AA）基因型且前瞻性随访0至6年的对照儿童的感染模式进行了比较。感染发生率和生存曲线分析均表明，SC病患儿的严重感染显著增加。呼吸道感染和肠胃炎是最常见的感染，但只有呼吸道感染在SC病中明显更频繁。肺炎球菌菌血症仅见于SC组。有和没有严重感染史的SC患者之间在血液学上没有明显差异，但在出现早期脾肿大的患者中感染明显更常见。
