Miura S, Ariyoshi Y, Yoshida M, Murai H, Yamamoto M, Niinomi M, Matsui N
Gan No Rinsho. 1983 Oct;29(12):1417-23.
Serum cortisol fractions were determined by isocolloidosmolar equilibrium dialysis in 93 women with breast cancer and 29 normal women. In breast cancer patients, the percentage of protein-unbound cortisol was increased at any concentration of total serum cortisol; this was accompanied by a relative decrease in the percentage of transcortin-bound cortisol. A significant increase in the unbound fraction is indicative of accelerated physiological activity of cortisol in breast cancer patients. In the breast cancer cases, there was a high incidence of obesity (61%) and impaired glucose tolerance (85%). In obese and/or diabetic patients, more remarkable increases of unbound cortisol were observed. We suggest that obesity and impaired glucose tolerance may increase the risk for breast cancer, and that the characteristic increase in the unbound cortisol fraction in women with breast cancer may reflect such risk factors.
采用等胶体渗透压平衡透析法测定了93例乳腺癌女性患者和29例正常女性的血清皮质醇组分。在乳腺癌患者中，无论血清总皮质醇浓度如何，未与蛋白结合的皮质醇百分比均升高；与此同时，皮质素结合皮质醇的百分比相对降低。未结合组分的显著增加表明乳腺癌患者体内皮质醇的生理活性加快。在乳腺癌病例中，肥胖发生率较高（61%），糖耐量受损发生率较高（85%）。在肥胖和/或糖尿病患者中，未结合皮质醇的增加更为显著。我们认为，肥胖和糖耐量受损可能会增加患乳腺癌的风险，乳腺癌女性患者未结合皮质醇组分的特征性增加可能反映了这些风险因素。
