Yuge O, Morio M, Fukui T, Fujii K, Kikuchi H, Takahashi S
Jpn J Surg. 1983 Jul;13(4):296-303. doi: 10.1007/BF02469510.
To determine the extent of maltose excreted into the urine, sugar substances present in the urine following intravenous infusion of maltose were analyzed. Maltose, glucose, maltotriose and maltotetraose in the urine were detected by gas chromatography and identified by mass spectrometric analysis. The total amounts of sugar substances excreted after 10 per cent maltose solution given at three different infusion rates were calculated. The excreted amounts of maltotriose and maltotetraose increased in a dose and time dependent manner. As these compounds were not detected in the plasma either during or after the administration of maltose, the kidney probably plays a role in the biosynthesis of maltotriose and maltotetraose. Studies on the organ homogenates of the rabbit showed that the enzyme activity for the biosynthesis of maltotriose from maltose was mainly in the kidney. The glucose excreted into the urine probably originates from maltose catalyzed to glucose, mainly by the action of kidney maltase. As the rate of excretion of sugar substances increased in a dose dependent manner, adequate infusion rates of maltose should be less than 0.5 g/kg/hour.
为了确定排泄到尿液中的麦芽糖含量，对静脉输注麦芽糖后尿液中存在的糖类物质进行了分析。通过气相色谱法检测尿液中的麦芽糖、葡萄糖、麦芽三糖和麦芽四糖，并通过质谱分析进行鉴定。计算了以三种不同输注速率给予10%麦芽糖溶液后排泄的糖类物质总量。麦芽三糖和麦芽四糖的排泄量呈剂量和时间依赖性增加。由于在给予麦芽糖期间或之后血浆中均未检测到这些化合物，肾脏可能在麦芽三糖和麦芽四糖的生物合成中起作用。对家兔器官匀浆的研究表明，由麦芽糖生物合成麦芽三糖的酶活性主要存在于肾脏中。排泄到尿液中的葡萄糖可能主要源于麦芽糖在肾脏麦芽糖酶作用下催化生成葡萄糖。由于糖类物质的排泄速率呈剂量依赖性增加，麦芽糖的合适输注速率应小于0.5 g/kg/小时。
