Spiegel R J, Schaefer E J, Magrath I T, Edwards B K
Leuk Res. 1983;7(5):647-54. doi: 10.1016/0145-2126(83)90135-2.
Abnormal diphenylhexatriene fluorescence polarization measurements (FP values) of plasma have previously been reported in patients with hematologic malignancies. However, the biological significance of this measurement is unclear. We have prospectively studied plasma from 39 patients with leukemia and lymphoma as well as normal donors for total cholesterol, total triglyceride, and lipoprotein-cholesterol fractions, and correlated these values with measured FP values. Total triglyceride, very low density lipoproteins (VLDL), high density lipoprotein (HDL) levels, and FP values were all strongly correlated with clinical and biochemical measures of tumor burden and varied directly with the presence of malignancy. Although the presence of abnormal FP values was confirmed in patients with leukemia and lymphoma, it was not a particularly sensitive measure for minimal tumor and it appeared to correlate directly with other measures of lipids and cholesterol, particularly triglyceride. It is suggested that further studies of conventional plasma lipids and lipoproteins be pursued in order to elucidate the apparently pervasive alterations in lipid metabolism present in these patients.
此前有报道称，血液系统恶性肿瘤患者血浆中双苯己三烯荧光偏振测量值（FP值）异常。然而，这一测量的生物学意义尚不清楚。我们前瞻性地研究了39例白血病和淋巴瘤患者以及正常供体的血浆中的总胆固醇、总甘油三酯和脂蛋白胆固醇组分，并将这些值与测得的FP值进行关联。总甘油三酯、极低密度脂蛋白（VLDL）、高密度脂蛋白（HDL）水平以及FP值均与肿瘤负荷的临床和生化指标密切相关，且与恶性肿瘤的存在呈直接相关。虽然白血病和淋巴瘤患者中FP值异常得到了证实，但它对微小肿瘤并非特别敏感的指标，且似乎与其他脂质和胆固醇指标，特别是甘油三酯直接相关。建议进一步研究传统血浆脂质和脂蛋白，以阐明这些患者中明显普遍存在的脂质代谢改变。
