Dobbin J M, Perkins J H
Laryngoscope. 1983 Dec;93(12):1540-3. doi: 10.1288/00005537-198312000-00003.
Acquired and congenital syphilis are both known causes of potentially reversible sensorineural hearing loss. Various therapeutic regimens, including penicillin and/or corticosteroids have been used in the past as treatment for otosyphilis. Response rates have varied from 15% to 80%. In this retrospective study, 13 patients with otosyphilis were treated with a combined course of long-term penicillin and prednisone. A significant response was defined as a 15% improvement in the discrimination score and/or the pure tone average. Initial response rates were 35% with a lasting response rate of 15%. Discrimination scores improved more commonly than pure tone averages. No patient with congenital syphilis or profound deafness had a lasting response. An analysis of possible reasons for failure of therapy is discussed.
获得性梅毒和先天性梅毒都是潜在可逆性感音神经性听力损失的已知病因。过去曾使用包括青霉素和/或皮质类固醇在内的各种治疗方案来治疗耳梅毒。有效率从15%到80%不等。在这项回顾性研究中，13例耳梅毒患者接受了长期青霉素和泼尼松联合疗程的治疗。显著反应定义为辨别分数和/或纯音平均听阈提高15%。初始有效率为35%，持久有效率为15%。辨别分数比纯音平均听阈更常得到改善。先天性梅毒患者或极重度聋患者均无持久反应。本文讨论了治疗失败可能原因的分析。
