Cheng K, Creacy S, Larner J
Mol Cell Biochem. 1983;56(2):177-82. doi: 10.1007/BF00227218.
Both insulin and lithium ion stimulated cytochalasin B-sensitive glucose transport in isolated rat adipocytes. As a result of enhanced glucose transport, the incorporation of [14C]glucose into CO2, glycogen and lipid were increased by both agents. However, the action of these two agents was distinguished. Cytochalasin B decreased insulin-stimulated glucose oxidation, glycogenesis and lipogenesis. In contrast, lithium-stimulated glycogenesis was decreased but lithium-stimulated glucose oxidation and lipogenesis were completely blocked. These results indicate that lithium ion in rat adipocytes has a specific insulin-like effect on glycogenesis without affecting glucose oxidation and lipogenesis.
胰岛素和锂离子均可刺激分离的大鼠脂肪细胞中对细胞松弛素B敏感的葡萄糖转运。由于葡萄糖转运增强，这两种物质均使[14C]葡萄糖掺入二氧化碳、糖原和脂质的量增加。然而，这两种物质的作用有所不同。细胞松弛素B可降低胰岛素刺激的葡萄糖氧化、糖原生成和脂肪生成。相比之下，锂刺激的糖原生成减少，但锂刺激的葡萄糖氧化和脂肪生成则完全被阻断。这些结果表明，大鼠脂肪细胞中的锂离子对糖原生成具有特定的胰岛素样作用，而不影响葡萄糖氧化和脂肪生成。
