Rubin J, Jones Q, Quillen E, Bower J D
Nephron. 1983;35(4):259-63. doi: 10.1159/000183093.
We describe two preparations for chronic peritoneal dialysis in the dog. In one group uremia was induced by nephrectomy and in the other by ureteral ligation. Peritoneal access was obtained using the Ash disc column catheter. Survival of the animals ranged from 27 to 83 days. Using a dialysis schedule similar in concept to continuous ambulatory peritoneal dialysis in man we found that dialysate-induced ultrafiltration, equilibration of solute between serum and dialysate, as well as protein losses into dialysate approximated values found in patients undergoing continuous ambulatory peritoneal dialysis. Careful attention to detail is required in order to maintain these animals. The advantages of these models are their technical simplicity and prolonged survival making intermediate range studies feasible. Disadvantages include anemia, seen in the anephric animals, technical problems with the disc column catheter, the need for maintenance of strict aseptic technique when performing dialysis exchanges, and difficulties maintaining adequate nutrition.
我们描述了两种犬慢性腹膜透析的制备方法。一组通过肾切除术诱导尿毒症，另一组通过输尿管结扎诱导尿毒症。使用阿什盘柱导管建立腹膜通路。动物的存活时间为27至83天。采用与人持续性非卧床腹膜透析概念相似的透析方案，我们发现透析液诱导的超滤、血清与透析液之间溶质的平衡以及透析液中的蛋白质损失接近接受持续性非卧床腹膜透析患者的数值。为了饲养这些动物，需要格外注重细节。这些模型的优点是技术简单且存活时间长，使进行中期研究成为可能。缺点包括无肾动物出现贫血、盘柱导管存在技术问题、进行透析交换时需要维持严格的无菌技术以及维持充足营养存在困难。
