[肌萎缩侧索硬化症（ALS）患者血清中的铜蓝蛋白和铜]

[Ceruloplasmin and copper in the serum of patients with amyotrophic lateral sclerosis (ALS)].

作者信息

Domzał T, Radzikowska B

出版信息

Neurol Neurochir Pol. 1983 May-Jun;17(3):343-6.

Abstract

The serum level of ceruloplasmin and copper were determined in 14 patients with ALS, 9 with Wilson's disease and 10 with other brain diseases. The enzyme level in 8 patients with ALS (57%) was decreased, similarly as in 8 with Wilson's disease (89%), and 2 (20%) in the control group. The mean ceruloplasmin level in the group of patients with Wilson's disease was 50% that in ALS patients. The copper level was decreased in only 1 ALS patient and 1 in the control group, while in patients with Wilson's disease it was low in 8 cases. These changes may be an effect as well as a cause of motor neuron disease.

摘要

对14例肌萎缩侧索硬化症（ALS）患者、9例威尔逊氏病患者和10例患有其他脑部疾病的患者测定了血清铜蓝蛋白和铜水平。8例ALS患者（57%）的酶水平降低，与8例威尔逊氏病患者（89%）类似，对照组中有2例（20%）降低。威尔逊氏病患者组的平均铜蓝蛋白水平为ALS患者组的50%。仅1例ALS患者和对照组中的1例铜水平降低，而威尔逊氏病患者中有8例铜水平较低。这些变化可能是运动神经元疾病的一个结果，也可能是其病因。