Cuomo V, Cagiano R, Brunello N, Fumagalli R, Racagni G
Neurosci Lett. 1983 Oct 10;40(3):315 -9. doi: 10.1016/0304-3940(83)90058-7.
Acute administration of desipramine, mianserin and viloxazine produces a significant decrease of locomotor activity in rats. Conversely, the locomotion of rats receiving the antidepressants for a prolonged period of time is not modified with respect to control animals. Moreover, the reserpine-induced decrement of locomotion is not influenced by chronic treatment with any of the antidepressants used in the present study. Since tolerance develops rapidly to these behavioural effects they may be indicative of compensatory changes in neuronal systems which may occur during prolonged antidepressant treatment.
急性给予地昔帕明、米安色林和维洛沙嗪会使大鼠的运动活动显著减少。相反，长时间接受抗抑郁药治疗的大鼠的运动与对照动物相比没有改变。此外，利血平引起的运动减少不受本研究中使用的任何一种抗抑郁药的慢性治疗的影响。由于对这些行为效应的耐受性迅速发展，它们可能表明在长期抗抑郁治疗期间神经元系统中可能发生的代偿性变化。
