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Biochemical and behavioral changes in rats after prolonged treatment with desipramine: interaction with p-chlorophenylalanine.

作者信息

Brunello N, Volterra A, Cagiano R, Ianieri G C, Cuomo V, Racagni G

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1985 Oct;331(1):20-2. doi: 10.1007/BF00498847.

DOI:10.1007/BF00498847
PMID:2933591
Abstract

The decrease in the Bmax value of 3H-dihydroalprenolol (3H-DHA) binding to cortical membranes of rat brain induced by long-term administration of desipramine (DMI) was prevented by concomitant treatment with parachlorophenylalanine (pCPA). Acute administration of DMI significantly decreased locomotor activity in saline- and (pCPA)-pretreated rats. DMI-induced inhibition of locomotor activity was abolished in (pCPA)-pretreated rats chronically treated with DMI. Conversely, in pCPA-pretreated animals, acute DMI could still significantly decrease the locomotion of chronically DMI-treated rats. The data presented indicate that an intact serotoninergic system is required to enable antidepressant drugs to induce biochemical and behavioral changes following their chronic administration.

摘要

相似文献

1
Biochemical and behavioral changes in rats after prolonged treatment with desipramine: interaction with p-chlorophenylalanine.
Naunyn Schmiedebergs Arch Pharmacol. 1985 Oct;331(1):20-2. doi: 10.1007/BF00498847.
2
Reevaluation of the regulation of beta-adrenergic receptor binding by desipramine treatment.通过地昔帕明治疗对β-肾上腺素能受体结合调节的重新评估。
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A pivotal role for serotonin (5HT) in the regulation of beta adrenoceptors by antidepressants: reversibility of the action parachlorophenylalanine by 5-hydroxytroptophan.
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4
Gangliosides enhance behavioral and neurochemical effects induced by chronic desipramine (DMI) treatment.
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Naunyn Schmiedebergs Arch Pharmacol. 1986 May;333(1):31-5. doi: 10.1007/BF00569656.
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引用本文的文献

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New perspectives on the molecular pharmacology of affective disorders.
Eur Arch Psychiatry Neurol Sci. 1989;238(5-6):231-9. doi: 10.1007/BF00449803.
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An investigation of the role of 5-hydroxytryptamine in the attenuation of presynaptic alpha 2-adrenoceptor-mediated responses by antidepressant treatments.5-羟色胺在抗抑郁治疗减弱突触前α2-肾上腺素能受体介导反应中的作用研究。
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Determination of the role of noradrenergic and 5-hydroxytryptaminergic neurones in postsynaptic alpha 2-adrenoceptor desensitization by desipramine and ECS.去甲丙咪嗪和电惊厥休克对去甲肾上腺素能和5-羟色胺能神经元在突触后α2-肾上腺素能受体脱敏中作用的测定

本文引用的文献

1
CLINICAL PHARMACOLOGY OF IMIPRAMINE AND RELATED ANTIDEPRESSANT COMPOUNDS.丙咪嗪及相关抗抑郁化合物的临床药理学
Pharmacol Rev. 1965 Jun;17:101-41.
2
Effects of bicuculline and chlordiazepoxide on locomotor activity and avoidance performance in rats.荷包牡丹碱和氯氮䓬对大鼠运动活动及回避行为的影响。
Experientia. 1980 Oct 15;36(10):1208-10. doi: 10.1007/BF01976133.
3
In vivo studies on central noradrenergic synaptic mechanisms after acute and chronic antidepressant drug treatment: biochemical and behavioral comparison.
Br J Pharmacol. 1991 Aug;103(4):1865-70. doi: 10.1111/j.1476-5381.1991.tb12343.x.
J Pharmacol Exp Ther. 1982 Oct;223(1):227-34.
4
Behavioural changes after acute and chronic administration of typical and atypical antidepressants in rats: interactions with reserpine.大鼠急性和慢性给予典型及非典型抗抑郁药后的行为变化：与利血平的相互作用
Neurosci Lett. 1983 Oct 10;40(3):315 -9. doi: 10.1016/0304-3940(83)90058-7.
5
Temporal sequence of changes in central noradrenergic system of rat after prolonged antidepressant treatment: receptor desensitization and neurotransmitter interactions.长期抗抑郁治疗后大鼠中枢去甲肾上腺素能系统变化的时间顺序：受体脱敏和神经递质相互作用。
Neuropharmacology. 1983 Mar;22(3 Spec No):415-24. doi: 10.1016/0028-3908(83)90191-0.
6
On the mode of action of imipramine: relationship between serotonergic axon terminal function and down-regulation of beta-adrenergic receptors.关于丙咪嗪的作用方式：5-羟色胺能轴突终末功能与β-肾上腺素能受体下调之间的关系。
Neuropharmacology. 1983 Mar;22(3 Spec No):373-83. doi: 10.1016/0028-3908(83)90186-7.
7
Down-regulation of beta-adrenergic receptors following repeated injections of desmethylimipramine: permissive role of serotonergic axons.重复注射去甲丙咪嗪后β-肾上腺素能受体的下调：5-羟色胺能轴突的允许作用
Neuropharmacology. 1982 Nov;21(11):1145-9. doi: 10.1016/0028-3908(82)90172-1.
8
Role of serotonergic input in the regulation of the beta-adrenergic receptor-coupled adenylate cyclase system.血清素能输入在β-肾上腺素能受体偶联腺苷酸环化酶系统调节中的作用。
Science. 1982 Nov 26;218(4575):900-1. doi: 10.1126/science.6291152.
9
Simultaneous determination of femtomole quantities of 5-hydroxytryptophan, serotonin and 5-hydroxyindoleacetic acid in brain using HPLC with electrochemical detection.采用高效液相色谱-电化学检测法同时测定脑中飞摩尔量的5-羟色氨酸、血清素和5-羟吲哚乙酸。
Eur J Pharmacol. 1981 Jan 29;69(3):347-52. doi: 10.1016/0014-2999(81)90481-7.
10
p-Chlorophenylalanine: a specific depletor of brain serotonin.对氯苯丙氨酸：一种脑血清素的特异性耗竭剂。
J Pharmacol Exp Ther. 1966 Dec;154(3):499-516.