Gergely T, Gabl F, Dorda W, Schnack H, Junker E, Bayer P M
Wien Klin Wochenschr. 1978 Jun 23;90(13):452-6.
Within the health-care program of Vienna 1577 volunteers (1203 female, 374 male persons) were screened for diabetes mellitus during 1975/76. Besides measurement of glucose tolerance one hour after the ingestion of 100 g glucose the following parameters were analyzed: cholesterol, triglycerides, uric acid and blood pressure. Male persons had a slightly decreased glucose tolerance; a distinct relationship with age was found in both sexes. After elimination of volunteers in whom pathological results were obtained with respect to other examined parameters, a significantly greater glucose tolerance was found in the remaining "normal" group. There are no parameters which are closely correlated with glucose tolerance although it was possible to reject the null-hypothesis in several cases due to the large sample involved. For statistical reasons (test sensitivity, test specificity, prevalence of disease) single glucose-tolerance measurements do not give enough evidence for diagnosing diabetes mellitus. Depending on the aims of the screening program one has to define the detection limits as well as frequency of retesting.
在维也纳的医疗保健项目中,1975/76年间对1577名志愿者(1203名女性,374名男性)进行了糖尿病筛查。除了测量摄入100克葡萄糖1小时后的糖耐量外,还分析了以下参数:胆固醇、甘油三酯、尿酸和血压。男性的糖耐量略有下降;男女两性均发现与年龄有明显关系。在排除了其他检测参数出现病理结果的志愿者后,在其余的“正常”组中发现糖耐量明显更高。尽管由于样本量较大,在几个案例中可以拒绝原假设,但没有与糖耐量密切相关的参数。出于统计原因(检测敏感性、检测特异性、疾病患病率),单次糖耐量测量不足以提供诊断糖尿病的充分证据。根据筛查项目的目标,必须确定检测限以及重新检测的频率。