阿替洛尔与美托洛尔在中枢神经系统副作用方面的比较。
A comparison between atenolol and metoprolol in respect of central nervous system side effects.
作者信息
Kirk C A, Cove-Smith R
出版信息
Postgrad Med J. 1983;59 Suppl 3(689):161-3.
A double-blind crossover study was performed to compare the incidence of central nervous system (CNS) side effects with atenolol and metoprolol. Eleven women and 6 men who had previously developed such side effects on lipophilic beta-blockers were identified by means of a preliminary questionnaire. A 30-item psychiatric questionnaire was then used to detect changes in psychological status and possible CNS side effects. Discontinuation of the original lipophilic beta-blocker produced a significant improvement in quality of sleep, dreams, concentration, memory, energy and anxiety. Introduction of atenolol did not result in any significant CNS effects. With metoprolol, however, some effects occurred but not to the extent experienced prior to study on other more lipophilic beta-blockers. Blood pressure control was identical with both drugs.
进行了一项双盲交叉研究，以比较阿替洛尔和美托洛尔的中枢神经系统（CNS）副作用发生率。通过一份初步问卷，确定了11名女性和6名男性，他们之前在使用亲脂性β受体阻滞剂时出现过此类副作用。随后使用一份包含30个项目的精神科问卷来检测心理状态的变化以及可能的中枢神经系统副作用。停用原来的亲脂性β受体阻滞剂后，睡眠质量、梦境、注意力、记忆力、精力和焦虑状况都有了显著改善。引入阿替洛尔未产生任何明显的中枢神经系统影响。然而，使用美托洛尔时出现了一些影响，但程度不及研究前使用其他更亲脂性β受体阻滞剂时。两种药物在血压控制方面效果相同。
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