β-肾上腺素受体阻滞剂美托洛尔和阿替洛尔与阿米替林之间的相互作用及其对肝脏氧化代谢的影响。
Interaction between the beta-adrenoceptor blockers metoprolol and atenolol with amitriptyline and their effects on oxidative liver metabolism.
作者信息
Kirch W, Spahn H, Kitteringham N R, Hutt H J, Mutschler E, Ohnhaus E E
出版信息
Br J Clin Pharmacol. 1984;17 Suppl 1(Suppl 1):65S-68S. doi: 10.1111/j.1365-2125.1984.tb02430.x.
Abstract
Neither the kinetics of the hydrophilic beta-adrenoceptor blocker atenolol nor those of the lipophilic metoprolol were influenced by the concurrent administration of amitriptyline. Compared with placebo, chronic administration (14 days) of atenolol and metoprolol (each as monotherapy) did not significantly reduce oxidative liver metabolism as measured by antipyrine half-life and by 6-beta-hydroxycortisol excretion. Compared with atenolol and metoprolol monotherapy, chronic administration of amitriptyline concurrently with each of the beta-adrenoceptor blockers produced an insignificant decrease (circa 10-20%) in antipyrine half-life and 6-beta-hydroxycortisol excretion. Amitriptyline appears therefore to have little enzyme-inducing activity.
摘要
亲水性β-肾上腺素能阻滞剂阿替洛尔及亲脂性美托洛尔的动力学均不受同时给予阿米替林的影响。与安慰剂相比，阿替洛尔和美托洛尔（均作为单一疗法）长期给药（14天）并未显著降低以安替比林半衰期和6-β-羟基皮质醇排泄量衡量的肝脏氧化代谢。与阿替洛尔和美托洛尔单一疗法相比，阿米替林与每种β-肾上腺素能阻滞剂同时长期给药，使安替比林半衰期和6-β-羟基皮质醇排泄量出现不显著的降低（约10%-20%）。因此，阿米替林似乎几乎没有酶诱导活性。
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本文引用的文献
1
Pharmacokinetics of atenolol in relation to renal function.阿替洛尔的药代动力学与肾功能的关系。
Eur J Clin Pharmacol. 1981 Jan;19(1):65-71. doi: 10.1007/BF00558387.
2
Atenolol kinetics in renal failure.阿替洛尔在肾衰竭中的动力学
Clin Pharmacol Ther. 1980 Sep;28(3):302-9. doi: 10.1038/clpt.1980.166.
3
Interaction of atenolol with furosemide and calcium and aluminum salts.
Clin Pharmacol Ther. 1981 Oct;30(4):429-35. doi: 10.1038/clpt.1981.184.
4
[Atenolol, pindolol and propranolol in essential hypertension: response rate and tolerance].阿替洛尔、吲哚洛尔和普萘洛尔治疗原发性高血压：有效率和耐受性
Schweiz Med Wochenschr. 1982 Dec 11;112(50):1831-5.
5
Lack of effect of atenolol on antipyrine clearance.阿替洛尔对安替比林清除率无影响。
Br J Clin Pharmacol. 1982 Nov;14(5):743-4. doi: 10.1111/j.1365-2125.1982.tb04967.x.
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The short term effects of propranolol, atenolol and labetalol on antipyrine kinetics in normal subjects.普萘洛尔、阿替洛尔和拉贝洛尔对正常受试者安替比林动力学的短期影响。
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