Tsiukhno Z I, Tkach F S, Voropaĭ T I
Probl Endokrinol (Mosk). 1983 Sep-Oct;29(5):12-5.
The radionuclide technique was used to study regional microcirculation in 139 patients with diabetic angiopathies of the lower limbs. All the examined demonstrated impairment of the muscular bloodflow, that increased depending on the disease stage and diabetes mellitus standing. No differences were recorded in the degree of bloodflow impairment in the muscles of patients treated with sulfanilurea drugs and insulin. Comparison of the degree of changes in the muscular bloodflow in diabetic angiopathies of the lower limbs and atherosclerosis obliterans of lower limb vessels in subjects without diabetes mellitus demonstrated that microcirculation in the former group patients was affected to a greater measure. It is desirable that the complex of therapeutic measures should include drugs that improve microcirculation at the early stages of the management of patients with diabetic angiopathies of the lower limbs.
采用放射性核素技术对139例下肢糖尿病血管病变患者的局部微循环进行了研究。所有受检者均显示肌肉血流受损,其受损程度随疾病阶段和糖尿病病程而增加。使用磺胺脲类药物和胰岛素治疗的患者,其肌肉血流受损程度无差异。对无糖尿病的下肢糖尿病血管病变患者与下肢血管闭塞性动脉粥样硬化患者的肌肉血流变化程度进行比较,结果表明,前一组患者的微循环受影响程度更大。在下肢糖尿病血管病变患者治疗的早期阶段,理想的治疗措施组合应包括改善微循环的药物。