Fowler S C, Lewis R M, Gramling S E, Nail G L
Pharmacol Biochem Behav. 1983 Nov;19(5):787-90. doi: 10.1016/0091-3057(83)90081-3.
By using operant conditioning techniques one group of 8 rats was trained to reach through a hole in the wall of an operant chamber, and to exert downward responses on a force-sensing circular disk. Eight other rats learned to reach through the hole and grasp and pull toward them a wire bail attached to a force transducer. Both behaviors were maintained on a fixed ratio 20 schedule of water reinforcement. The effects of chlordiazepoxide (CDP, 2.5, 5.0, 10.0 mg/kg) on response force and rate were assessed for both groups. CDP significantly increased response force in a dose-related manner in both groups; regardless of topography, response rate was little affected by the 2.5- and 5.0 mg/kg doses but was decreased by the highest dose. Results were discussed in terms of CDP's antipunishment and neuromuscular effects.
通过运用操作性条件反射技术，一组8只大鼠被训练通过操作箱壁上的一个洞伸出，并对一个力传感圆盘施加向下的反应。另外8只大鼠学会通过这个洞伸出并抓住连接到力传感器的金属丝环并向自己拉动。两种行为都按照固定比例20的水强化程序维持。评估了氯氮卓（CDP，2.5、5.0、10.0毫克/千克）对两组大鼠反应力和速率的影响。CDP在两组中均以剂量相关的方式显著增加反应力；无论行为表现形式如何，2.5毫克/千克和5.0毫克/千克剂量对反应速率影响很小，但最高剂量使其降低。根据CDP的抗惩罚和神经肌肉作用对结果进行了讨论。
