Szentmiklósi P, Marton S
Pharmazie. 1983 Sep;38(9):611-3.
The absorption of Depogen was studied on an in vitro model and in various laboratory animals using stoichiometrically equivalent doses of drotaverin (No-Spa) calculated for drotaverin base for comparison. Blood levels of the drug were assessed by radiochemical and microchemical methods. Based on the results obtained and pharmacokinetic properties, the expectable optimal dosage and formulations for the possible field of indication were elaborated.
在体外模型和各种实验动物身上研究了地波琼的吸收情况，并使用按地屈维林碱计算的化学计量等效剂量的屈他维林（No-Spa）进行比较。通过放射化学和微量化学方法评估药物的血药浓度。根据所得结果和药代动力学特性，制定了针对可能适应症领域的预期最佳剂量和剂型。
