Gyarmati L, Dávid A, Mészáros Z, Rácz I, Szentmiklósi P
Pharmazie. 1975 Mar;30(3):174-7.
Studying the metabolism of drotaverin (No-Spa¿), we have elaborated a method for the isolation, purification and separation of metabolites and of drotaverin excreted in unchanged form in the urine and feces. The structure of the chief metabolites was cleared by t.l.c., polarography, UV spectrophotometry, and mass spectrometry. It was stated that beside drotaverin excreted in unchanged form, the biotransformation of the molecule results in the formation of oxidation and desalkylation products.
在研究屈他维林（No-Spa®）的代谢过程中，我们精心设计了一种方法，用于分离、纯化和区分代谢产物以及以未改变形式排泄于尿液和粪便中的屈他维林。主要代谢产物的结构通过薄层色谱法、极谱法、紫外分光光度法和质谱法得以明确。结果表明，除了以未改变形式排泄的屈他维林外，该分子的生物转化还会导致氧化和脱烷基产物的形成。
