Pokorný J, Trojan S
Physiol Bohemoslov. 1983;32(5):393-402.
The structure of pyramidal cells in the CA1 hippocampal region, impregnated by the Golgi-Cox method, was studied in adult rats which had been repeatedly exposed to aerogenic hypoxia from birth till the 17th day of life. The length of basal dendrite branches was the same in the experimental and control animals. The branches of apical dendrites were longer after hypoxia [p less than 0.01] due to the higher number of proximal lateral dendrites [p less than 0.01]. On the other hand, a smaller number of branches was found in the distal parts of apical dendrites. The density of spines upon selected standard segments of the branches was decreased [p less than 0.01]. The spines of these animals had a shorter stem, and were more robust and club shaped. The structural differences in the hippocampus, caused by the hypoxia in the first weeks of life, were resistuted during the subsequent development only partially. Changes in the extent and arrangement of the neuronal receptive field, similarly as the transmission properties of dendritic spines, present in adult rats, may be the cause of some functional changes in hippocampal neuronal circuits.
采用高尔基-考克斯法对出生至生后第17天反复暴露于气源性缺氧的成年大鼠海马CA1区锥体细胞结构进行了研究。实验动物和对照动物的基底树突分支长度相同。缺氧后顶树突的分支更长[p<0.01]，这是由于近端外侧树突数量更多[p<0.01]。另一方面，在顶树突的远端部分发现分支数量较少。所选标准分支段上的棘密度降低[p<0.01]。这些动物的棘茎较短，更粗壮且呈棒状。出生后第一周的缺氧导致的海马结构差异在随后的发育过程中仅部分得到恢复。成年大鼠中神经元感受野范围和排列的变化，与树突棘的传递特性类似，可能是海马神经元回路某些功能变化的原因。
