Langmeier M, Pokorný J, Mares J, Trojan S
Institute of Physiology, Faculty of Medicine, Charles University, Prague, Czechoslovakia.
Biomed Biochim Acta. 1989;48(2-3):S204-7.
Structural parameters of neuronal circuits were studied in rats exposed to aerogenic hypoxia during the postnatal development. In 18-day-old experimental animals pyramidal cells of the hippocampal CA1 area had less branches of the apical dendrites. These branches were shorter with lower dendritic spine density. Myelinated axons in the corpus callosum were less frequent. In electron-microscopic picture the mean section area of myelinated axons was lower, the myelin sheets were thinner and consisted of less myelin layers. Synapses in the II. layer of the somatosensoric cortex had more often flat pre-synaptic dense projections, smaller width between pre- and post-synaptic densities and thinner post-synaptic densities.
在出生后发育过程中暴露于气体性缺氧的大鼠中，研究了神经回路的结构参数。在18日龄的实验动物中，海马CA1区的锥体细胞顶树突分支较少。这些分支较短，树突棘密度较低。胼胝体中的有髓轴突较少见。在电子显微镜图像中，有髓轴突的平均横截面积较小，髓鞘较薄且由较少的髓鞘层组成。体感皮层II层中的突触更常出现扁平的突触前致密突起，突触前和突触后致密物之间的宽度较小，突触后致密物较薄。
