Buonanno F S, Kistler J P, DeWitt L D, Davis K R, DeLaPaz R, New P F, Burt C T, Brady T J
Semin Nucl Med. 1983 Oct;13(4):329-38. doi: 10.1016/s0001-2998(83)80045-2.
From the preliminary work of many investigators, it appears that proton nuclear magnetic resonance (NMR) imaging will have wide application in the diagnostic assessment (and potential management) of patients with vascular, neoplastic, and demyelinating diseases of the central nervous system (CNS). Findings in isolated cases and small series suggest that NMR imaging may play a role in the evaluation of patients with other CNS conditions including hydrocephalus, malformations, infections, developmental and metabolic disorders, and degenerative processes. Because of the dynamic nature of disease processes involving the CNS, the precise meaning of NMR image parameters (rho, T1, and T2) remains unclear. A comprehensive study correlating NMR images in neurologic disease with precise neuropathologic examination is required. In the future, with accurate quantitative measurements of these NMR parameters, in vivo imaging may provide insight into the dynamic nature of neurologic disease.
从众多研究者的初步工作来看，质子核磁共振（NMR）成像似乎将在中枢神经系统（CNS）血管性、肿瘤性和脱髓鞘疾病患者的诊断评估（以及潜在治疗）中得到广泛应用。个别病例和小样本系列研究的结果表明，NMR成像可能在评估患有其他CNS疾病的患者中发挥作用，这些疾病包括脑积水、畸形、感染、发育和代谢障碍以及退行性病变。由于涉及CNS的疾病过程具有动态性，NMR图像参数（ρ、T1和T2）的确切含义仍不明确。需要进行一项将神经疾病中的NMR图像与精确的神经病理学检查相关联的综合研究。未来，通过对这些NMR参数进行准确的定量测量，活体成像可能会深入了解神经疾病的动态本质。
