Marshall L R, Herrmann R P
Thromb Haemost. 1983 Oct 31;50(3):707-11.
A systematic study was made of the action on the plasma coagulation system of 20 Australian and Papuan Elapid and Hydrophiid snake venoms and compared with 4 Crotalid venoms and 1 Viper. The majority of Australian venoms were shown to be prothrombin activators with variable dependence on the presence of factor V phospholipid and calcium. None of these venoms had strong thrombin like activity in contrast to the Crotalid venoms which were powerfully thrombin like. The Crotalid venoms were also strongly fibrinolytic unlike the Elapid venoms which showed no or minimal evidence of fibrinolytic activity. Four Elapid venoms and 2 Crotalid venoms showed anticoagulant activity which contained neither antithrombin nor fibrinogenolytic activity and may act upon the prothrombin complex.
对20种澳大利亚和巴布亚眼镜蛇科及海蛇科蛇毒对血浆凝固系统的作用进行了系统研究，并与4种蝰蛇科蛇毒和1种蝰蛇进行了比较。结果表明，大多数澳大利亚蛇毒是凝血酶原激活剂，对因子V、磷脂和钙的依赖性各不相同。与具有强大凝血酶样活性的蝰蛇科蛇毒不同，这些蛇毒均无强烈的凝血酶样活性。蝰蛇科蛇毒也具有很强的纤维蛋白溶解作用，而眼镜蛇科蛇毒则没有或仅有极微量的纤维蛋白溶解活性。4种眼镜蛇科蛇毒和2种蝰蛇科蛇毒表现出抗凝活性，既不含抗凝血酶也无纤维蛋白原溶解活性，可能作用于凝血酶原复合物。
