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正常和受伤大鼠肝脏中激肽原和激肽原酶的合成

Kininogen and kininogenase synthesis by the liver of normal and injured rats.

作者信息

Borges D R, Gordon A H

出版信息

J Pharm Pharmacol. 1976 Jan;28(1):44-8. doi: 10.1111/j.2042-7158.1976.tb04021.x.

DOI:10.1111/j.2042-7158.1976.tb04021.x
PMID:6649
Abstract

Isolated livers from normal rats or from others at 2 days after subcutaneous injection of turpentine have been perfused with a simplified medium. Estimation of kininogen, kininogenase and 2 plasma proteins in the perfusates thus obtained indicate that both kininogen and kininogenase are synthesized in the liver. Furthermore, because twice as much kininogen and kininogenase was synthesized by the livers from the rats which had been injected with turpentine as by those from the normal rats, these two proteins must be considered to be members of the group of plasma proteins known as acute phase reactants.

摘要

已用一种简化培养基对正常大鼠或皮下注射松节油2天后的其他大鼠的离体肝脏进行灌注。对如此获得的灌注液中的激肽原、激肽原酶和两种血浆蛋白的测定表明,激肽原和激肽原酶均在肝脏中合成。此外,由于注射松节油的大鼠的肝脏合成的激肽原和激肽原酶是正常大鼠肝脏合成量的两倍,因此这两种蛋白质必须被视为已知的急性期反应物血浆蛋白组的成员。

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1
Kininogen and kininogenase synthesis by the liver of normal and injured rats.正常和受伤大鼠肝脏中激肽原和激肽原酶的合成
J Pharm Pharmacol. 1976 Jan;28(1):44-8. doi: 10.1111/j.2042-7158.1976.tb04021.x.
2
Sex dimorphism and inflammatory regulation of T-kininogen and T-kininogenase.T-激肽原和T-激肽原酶的性别二态性与炎症调节
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Lack of expression of T-kininogen gene in the hearts of untreated and turpentine-injected rats.未处理及注射松节油的大鼠心脏中T-激肽原基因的表达缺失。
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Substrate specificities of tissue kallikrein and T-kininogenase: their possible role in kininogen processing.组织激肽释放酶和T-激肽原酶的底物特异性:它们在激肽原加工中的可能作用。
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引用本文的文献

1
Pro-inflammatory properties of the kallikrein-kinin system: potential for new drug therapy.激肽释放酶-激肽系统的促炎特性:新药物治疗的潜力。
Inflammopharmacology. 1998;6(4):289-96. doi: 10.1007/s10787-998-0013-5.
2
The mechanism of the anti-inflammatory effect of turpentine in the rat.松节油在大鼠体内的抗炎作用机制。
Naunyn Schmiedebergs Arch Pharmacol. 1984 Sep;327(2):143-7. doi: 10.1007/BF00500909.
3
Acute turpentine inflammation and kinin release in rat-paw thermic oedema.大鼠爪热水肿中的急性松节油炎症和激肽释放
Br J Exp Pathol. 1981 Dec;62(6):591-4.
4
Involvement of inflammatory leukocytes in hepatic induction of T-kininogen in rat.炎症性白细胞在大鼠肝脏诱导T-激肽原中的作用。
Inflammation. 1987 Sep;11(3):345-52. doi: 10.1007/BF00915838.
5
Further studies of the mechanism of counter irritation by turpentine.松节油反向刺激作用机制的进一步研究。
Naunyn Schmiedebergs Arch Pharmacol. 1986 Feb;332(2):196-200. doi: 10.1007/BF00511412.
6
The clearance rate of plasma kallikrein by the liver increases during the acute-phase response to inflammation.在对炎症的急性期反应期间,肝脏对血浆激肽释放酶的清除率会增加。
Agents Actions. 1992 Sep;37(1-2):111-3. doi: 10.1007/BF01987898.
7
The renal kallikrein-kinin system in human and in experimental hypertension.人类及实验性高血压中的肾激肽释放酶-激肽系统
Klin Wochenschr. 1978;56 Suppl 1:113-25. doi: 10.1007/BF01477462.