松节油在大鼠体内的抗炎作用机制。
The mechanism of the anti-inflammatory effect of turpentine in the rat.
作者信息
Damas J, Deflandre E
出版信息
Naunyn Schmiedebergs Arch Pharmacol. 1984 Sep;327(2):143-7. doi: 10.1007/BF00500909.
The influence of counter irritation by turpentine on carrageenan-oedema, leucocyte count, plasma kininogen stores and composition of sponge-induced exudates has been investigated in the rat. Counter irritation reduced the carrageenan-oedema in normal as well as in adrenalectomized rats. It induced leucopenia with lymphopenia but did not modify the plasma kininogen stores. In turpentine-pretreated rats, the exudates induced by sponge implantation 18 h previously had a lower content in leucocytes. Their levels in beta-glucuronidase and beta-galactosidase were slightly reduced, their content in PGE2 was not modified and their level in malonaldehyde was increased. The exudates induced by sponge implantation 4 h previously had a lower content in leucocytes and PGE2 while their level in kinins was not modified. The mechanism of the anti-inflammatory effect of counter irritation by turpentine is discussed. We suggest that the main factor involved is a decrease in leucocyte accumulation into the exudates.
在大鼠身上研究了松节油反向刺激对角叉菜胶性水肿、白细胞计数、血浆激肽原储备以及海绵诱导渗出物成分的影响。反向刺激降低了正常大鼠和肾上腺切除大鼠的角叉菜胶性水肿。它引起白细胞减少并伴有淋巴细胞减少，但未改变血浆激肽原储备。在预先用松节油处理的大鼠中，18小时前植入海绵诱导的渗出物中白细胞含量较低。它们的β-葡萄糖醛酸酶和β-半乳糖苷酶水平略有降低，PGE2含量未改变，丙二醛水平升高。4小时前植入海绵诱导的渗出物中白细胞和PGE2含量较低，而激肽水平未改变。讨论了松节油反向刺激的抗炎作用机制。我们认为主要涉及的因素是渗出物中白细胞积聚的减少。
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