Stromberg P C, Vogtsberger L M
Vet Pathol. 1983 Nov;20(6):698-708. doi: 10.1177/030098588302000605.
Pathological evaluations were done in 205 rats with mononuclear cell leukemia. Leukemia was diagnosed in 22.2% of males and 20.4% of females with significant risk beginning at 20 months of age. Mononuclear cell leukemia was responsible for 50% of early deaths in two-year studies. Clinically, rats became depressed, pale, icteric and had palpably enlarged spleens. Gross lesions included splenomegaly, enlarged mesenteric lymph nodes, and mottled livers. Hemorrhages occurred in the lungs, brain, and lymph nodes. Histological examination demonstrated that spleen and liver were most consistently and seriously involved, although numerous other organs contained leukemic infiltrates of variable severity. Spleens exhibited diffuse leukemic infiltration of the red pulp, follicular lymphoid depletion, and decrease in both extramedullary hematopoiesis and hemosiderin. Liver lesions consisted of diffuse centrilobular degeneration and necrosis. Erythrophagocytosis by tumor cells was common in the spleen and observed in liver, lymph nodes, and adrenals. The disease appeared to originate in the spleen. Bone marrow infiltration occurred late relative to spleen involvement and was present in less than half of the rats.
对205只患单核细胞白血病的大鼠进行了病理评估。在20个月龄开始出现显著风险的大鼠中，22.2%的雄性和20.4%的雌性被诊断患有白血病。在为期两年的研究中，单核细胞白血病导致了50%的早期死亡。临床上，大鼠变得抑郁、苍白、黄疸，脾脏明显肿大。大体病变包括脾肿大、肠系膜淋巴结肿大和肝脏斑驳。肺、脑和淋巴结出现出血。组织学检查表明，脾脏和肝脏受累最为持续和严重，尽管许多其他器官也有不同程度的白血病浸润。脾脏表现为红髓弥漫性白血病浸润、滤泡性淋巴细胞耗竭，以及髓外造血和含铁血黄素减少。肝脏病变包括弥漫性小叶中心变性和坏死。肿瘤细胞吞噬红细胞在脾脏中很常见，在肝脏、淋巴结和肾上腺中也可观察到。该病似乎起源于脾脏。相对于脾脏受累，骨髓浸润出现较晚，且不到一半的大鼠出现骨髓浸润。
