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[不同类型高脂蛋白血症患者的高密度脂蛋白胆固醇与致动脉粥样硬化指数]

[High-density lipoprotein cholesterol and the atherogenic index in patients with different types of hyperlipoproteinemias].

作者信息

Apostolov I, Naumova R, Balabanski L, Goranov I

出版信息

Vutr Boles. 1983;22(3):70-4.

PMID:6649586
Abstract

A total of 180 subjects (82 males and 98 females), aged from 20 to 60 were examined. Sixty four of them (29 males and 35 females) were regular blood donors (control group) and 116 subjects (53 males and 63 females) - with huperlipoproteinemias: type IIa - 50 subjects (17 males and 33 females), type IIb - 37 (23 males and 14 females) and type IV - 29 (13 males and 16 females). Triglycerides, total cholesterol and cholesterol in lipoproteins with high density (Ch-HDLP) were also determined. The percentage of Ch-HDLP was calculated from total cholesterol (TCh) as well as the atherogenic index [(TCh-Ch-HDLP): Ch-KDLP)] A drop down of Ch-HDLP (p less than 0,01) was found only in hyperlipoproteinemia type IV, as compared with the control group. Ch-HDLP percentage was diminished (p less than 0,001) whereas the atherogenic index was increased (p less than 0,001) in hyperlipoproteinemias from the three types. Both sexes were affected by the changes decrided.

摘要

共检查了180名年龄在20至60岁之间的受试者(82名男性和98名女性)。其中64人(29名男性和35名女性)为定期献血者(对照组),116名受试者(53名男性和63名女性)患有高脂蛋白血症:IIa型50人(17名男性和33名女性),IIb型37人(23名男性和14名女性),IV型29人(13名男性和16名女性)。还测定了甘油三酯、总胆固醇和高密度脂蛋白中的胆固醇(Ch-HDLP)。Ch-HDLP的百分比由总胆固醇(TCh)计算得出,同时还计算了致动脉粥样硬化指数[(TCh-Ch-HDLP):Ch-KDLP]。与对照组相比,仅在IV型高脂蛋白血症中发现Ch-HDLP下降(p<0.01)。在这三种类型的高脂蛋白血症中,Ch-HDLP百分比降低(p<0.001),而致动脉粥样硬化指数升高(p<0.001)。两性均受这些变化的影响。

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