Walde A, Ve B, Scheline R R, Monge P
Xenobiotica. 1983 Aug;13(8):503-12. doi: 10.3109/00498258309052290.
The metabolism of p-cymene was studied in rats and guinea-pigs. Following intragastric or inhalation dosage (100 mg/kg) urinary metabolite excretion was nearly complete within 48 h, amounting to 60-80% dose. The inhalation experiments gave the lowest values. 18 urinary metabolites were detected and identified. Of these, rats did not excrete two and guinea-pigs did not excrete a third. No ring-hydroxylation of p-cymene was detected in rats, but guinea-pigs formed small amounts of carvacrol and hydroxycarvacrol. Oxidation of both the methyl and isopropyl groups of p-cymene occurred extensively in both species. The following types of metabolites were formed: monohydric alcohols, diols, mono- and di-carboxylic acids and hydroxyacids. Conjugation with glycine of the cumic acid formed was extensive in guinea-pigs.
在大鼠和豚鼠体内研究了对伞花烃的代谢情况。经胃内或吸入给药（100毫克/千克）后，48小时内尿液代谢物排泄几乎完成，排泄量达剂量的60 - 80%。吸入实验得到的值最低。检测并鉴定出18种尿液代谢物。其中，大鼠不排泄两种，豚鼠不排泄第三种。在大鼠中未检测到对伞花烃的环羟基化，但豚鼠形成了少量香芹酚和羟基香芹酚。对伞花烃的甲基和异丙基在两种动物中均广泛发生氧化。形成了以下几种代谢物类型：一元醇、二醇、一元和二元羧酸以及羟基酸。豚鼠体内形成的枯酸与甘氨酸的结合作用广泛。
