Janisch H D, Eckardt V F
Z Gastroenterol. 1983 Oct;21(10):574-9.
The aim of this study was to determine the effect of dry and wet swallows on oesophageal contractions in patients with oesophageal motility disorders (achalasia, diffuse oesophageal spasm and "intermediate" motility disorders). Wet swallows resulted in greater amplitude of oesophageal contractions than did dry swallows, both in patients with oesophageal motility disorders and controls. In patients with oesophageal motility disorders wet swallows were also followed by a greater incidence of repetitive contractions than dry swallows. This increased incidence of abnormal contractions correlated significantly with the increase in oesophageal baseline pressure during wet swallows. The administration of pentagastrin further increased the amplitude and duration of oesophageal contractions in patients with oesophageal motility disorders, but the incidence of abnormal contractions remained unaltered. It is concluded that wet swallows compared to dry swallows pronounce the abnormality of oesophageal contractions in patients with oesophageal motility disorders.
本研究的目的是确定干咽和湿咽对食管动力障碍（贲门失弛缓症、弥漫性食管痉挛和“中间型”动力障碍）患者食管收缩的影响。无论是食管动力障碍患者还是对照组，湿咽导致的食管收缩幅度均大于干咽。在食管动力障碍患者中，湿咽后重复收缩的发生率也高于干咽。这种异常收缩发生率的增加与湿咽时食管基线压力的升高显著相关。给予五肽胃泌素进一步增加了食管动力障碍患者食管收缩的幅度和持续时间，但异常收缩的发生率保持不变。结论是，与干咽相比，湿咽使食管动力障碍患者的食管收缩异常更为明显。
