Ferriolli E, Dantas R O, Oliveira R B, Braga F J
Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
Eur J Gastroenterol Hepatol. 1996 Aug;8(8):793-8.
To verify the influence of ageing on oesophageal motility elicited by the swallowing of liquids with different viscosities.
In order to study the effect of ageing on oesophageal function, healthy volunteers of three age groups were studied by manometric and scintigraphic methods during the swallowing of water and a high viscosity liquid.
Forty healthy volunteers (20 aged 20 to 30 years, 10 aged 50 to 60 years and 10 aged 70 to 80 years) were submitted to oesophageal manometry during 10 swallows of water, 10 swallows of sugar cane syrup and 10 "dry' swallows. Basal pressure of the upper oesophageal sphincter and the lower oesophageal sphincter, amplitude, duration and velocity of contraction and the duration of the lower oesophageal sphincter relaxation were measured. Morphology and peristalsis of contractile waves were studied. The same volunteers underwent scintigraphic oesophageal transit studies with the same boluses. Oesophageal clearance time and patterns of transit were studied.
Water and sugar cane syrup did not differ as to quantitative contraction parameters, but sugar cane syrup led to a higher incidence of synchronous contractions. The three age groups had similar amplitude and velocity of contractile waves. The youngest group had shorter duration of contractile waves 10 and 5 cm above the lower oesophageal sphincter. The oldest group had markedly more frequent synchronous contractions and failures of contraction after both water and sugar cane syrup swallows. This was associated with a high incidence of scintigraphic transit abnormalities in this group.
Abnormal oesophageal peristalsis and incomplete oesophageal emptying of both low and high viscosity liquids are significantly more frequent in healthy elderly persons than in younger persons.
验证衰老对吞咽不同黏度液体时食管动力的影响。
为研究衰老对食管功能的影响，采用测压法和闪烁扫描法，对三个年龄组的健康志愿者在吞咽水和高黏度液体时进行了研究。
40名健康志愿者（20名年龄在20至30岁之间，10名年龄在50至60岁之间，10名年龄在70至80岁之间）在吞咽10次水、10次甘蔗糖浆和10次“干”吞咽过程中接受食管测压。测量食管上括约肌和下括约肌的基础压力、收缩幅度、持续时间和速度以及下食管括约肌松弛的持续时间。研究收缩波的形态和蠕动。相同的志愿者用相同的团块进行闪烁扫描食管通过研究。研究食管清除时间和通过模式。
水和甘蔗糖浆在定量收缩参数方面没有差异，但甘蔗糖浆导致同步收缩的发生率更高。三个年龄组的收缩波幅度和速度相似。最年轻的组在下食管括约肌上方10厘米和5厘米处的收缩波持续时间较短。最年长的组在吞咽水和甘蔗糖浆后同步收缩和收缩失败明显更频繁。这与该组闪烁扫描通过异常的高发生率相关。
健康老年人中，低黏度和高黏度液体的食管蠕动异常和食管排空不完全的情况明显比年轻人更频繁。
