Ebner E, Birkigt H G, Riedel E, Sedlarik K, Fritzsche L
Z Exp Chir Transplant Kunstliche Organe. 1983;16(5):292-300.
Concerning the effect of the perfusion of ischemic areas of the myocardium by a stroma-free hemoglobin solution was reported after the starvation of the interventricular branch of the left coronary artery (RIVA) in minipigs. The effect of the perfusion is dependent on the kind of the vascular course. The perfusion of the distal part of the starvated coronary artery shows the better reaction in face of the artemalization of the concomitant cardiac vein with regard to the resaturation of the myocardium with oxygen and several hemodynamic control parameters. Histologic examinations of the ischemic myocardium after the arterialization of the cardiac veins showed however that the symplasm preserved its vitality and showed only reversible changes. The applied stroma-free hemoglobin solution needs a further development. However, the use is possible on principle according to the bibliography. Whether a new clinical therapy could be developed by a transitory arterialization of the cardiac veins in acute myocardial ischemia, should be discussed.
在小型猪左冠状动脉室间隔支（RIVA）饥饿后，有关于无基质血红蛋白溶液灌注心肌缺血区域效果的报道。灌注效果取决于血管走行类型。就心肌氧再饱和及几个血流动力学控制参数而言，饥饿冠状动脉远端的灌注在伴行心脏静脉动脉化方面显示出更好的反应。然而，心脏静脉动脉化后对缺血心肌的组织学检查表明，共质体保持了其活力，仅显示出可逆性变化。所应用的无基质血红蛋白溶液需要进一步改进。不过，根据文献，原则上是可以使用的。是否可以通过急性心肌缺血时心脏静脉的短暂动脉化开发出一种新的临床治疗方法，值得探讨。
