Bogdan C, Balmer J A, Liechti A
Zentralbl Gynakol. 1978;100(8):510-15.
Orally administered PGE2 in tablet form was used to induce labour in a prospective trial on 57 patients. The prostaglandin was given in separate-hourly-dosis of 0,5 to 1,5 mg. The success rate of this oral induction was 93%. Frequency of acidotic and/or clinically depressed newborns and the incidence of active delivery reflected the unselected population. A precipitant labour was noted in one patient, while 23% showed symptoms of gastrointestinal side effects which were seen to be dosage dependent.
在一项针对57名患者的前瞻性试验中,使用口服片剂形式的PGE2来引产。前列腺素以每小时0.5至1.5毫克的剂量分次给药。这种口服引产的成功率为93%。酸中毒和/或临床抑郁新生儿的发生率以及活跃分娩的发生率反映了未经过筛选的人群情况。有一名患者出现急产,而23%的患者表现出胃肠道副作用症状,且这些症状被认为与剂量有关。