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呋喃香豆素的光敏作用:单线态氧的可能作用。

Photosensitized effects of furocoumarins: the possible role of singlet oxygen.

作者信息

Vedaldi D, Dall'Acqua F, Gennaro A, Rodighiero G

出版信息

Z Naturforsch C Biosci. 1983 Sep-Oct;38(9-10):866-9. doi: 10.1515/znc-1983-9-1033.

DOI:10.1515/znc-1983-9-1033
PMID:6649795
Abstract

The capacity of various furocoumarins to generate singlet oxygen in aqueous solution has been determined. The antiproliferative and the skin-photosensitizing activities of the same furocoumarins did not show any correlation with the capacity to generate the singlet oxygen, while these photobiological properties could be correlated with the capacity of furocoumarins to induce photolesions to the DNA.

摘要

已测定了各种呋喃香豆素在水溶液中产生单线态氧的能力。相同呋喃香豆素的抗增殖和皮肤光敏活性与产生单线态氧的能力没有任何相关性,而这些光生物学特性可能与呋喃香豆素诱导DNA光损伤的能力相关。

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