Morady F, Scheinman M M, Hess D S, Chen R, Stanger P
Am Heart J. 1983 Dec;106(6):1306-14. doi: 10.1016/0002-8703(83)90038-8.
Thirty-one patients 16 to 40 years of age (mean +/- SD = 30.7 +/- 7 years) had one or more episodes of sustained ventricular tachycardia (VT) or ventricular fibrillation (VF). Underlying cardiac abnormalities consisted most commonly of cardiomyopathy (nine), long QT syndrome (LQTS) (five), and mitral valve prolapse (five); no identifiable heart disease was found in four patients. Programmed ventricular stimulation induced VT in only one of four patients with the LQTS but induced VT in 64% of 22 patients with other abnormalities. Chronic drug treatment was based either on serial electropharmacologic testing or was empiric when electrophysiologic testing failed to provoke an arrhythmia. Using this approach, we found a 13% incidence of recurrent VT and a 10% mortality over a follow-up period of 18.1 +/- 13.9 months. In young adults with VT or VF, an underlying cardiac abnormality can usually be found. Extensive evaluation should be performed to uncover the underlying cardiac abnormality as this may influence chronic management.
31例年龄在16至40岁之间（平均±标准差=30.7±7岁）的患者发生过一次或多次持续性室性心动过速（VT）或心室颤动（VF）。潜在的心脏异常最常见的是心肌病（9例）、长QT综合征（LQTS）（5例）和二尖瓣脱垂（5例）；4例患者未发现可识别的心脏病。程序性心室刺激仅在4例LQTS患者中的1例诱发了VT，但在22例有其他异常的患者中，64%诱发了VT。慢性药物治疗要么基于系列电药理学测试，要么在电生理测试未能诱发心律失常时凭经验进行。采用这种方法，在18.1±13.9个月的随访期内，我们发现复发性VT的发生率为13%，死亡率为10%。在患有VT或VF的年轻成年人中，通常可以发现潜在的心脏异常。应进行广泛评估以发现潜在的心脏异常，因为这可能会影响慢性治疗。
