Varma R N, Mankad V N, Phelps D D, Jenkins L D, Suskind R M
Am J Clin Nutr. 1983 Dec;38(6):884-7. doi: 10.1093/ajcn/38.6.884.
In a group of 27 sickle cell disease patients ranging in age from 2 yr 3 months to 43 yr, 13 (48%) were found to have depressed erythrocyte glutathione reductase activity suggesting riboflavin deficiency. Glutathione reductase activity coefficients did not correlate with riboflavin intakes which were calculated from 3-day diet records returned by 16 patients. Other causes of riboflavin deficiency including decreased absorption, altered metabolism, or increased excretion of the vitamin must be considered. The potential effect of depressed erythrocyte glutathione reductase activity in the sickle cell disease process is discussed.
在一组年龄从2岁3个月至43岁的27例镰状细胞病患者中，发现13例（48%）红细胞谷胱甘肽还原酶活性降低，提示核黄素缺乏。谷胱甘肽还原酶活性系数与根据16例患者返回的3天饮食记录计算出的核黄素摄入量不相关。必须考虑核黄素缺乏的其他原因，包括吸收减少、代谢改变或该维生素排泄增加。文中讨论了红细胞谷胱甘肽还原酶活性降低在镰状细胞病发病过程中的潜在影响。
