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[急性二氯乙烷中毒所致神经系统疾病]

[Neurologic disorders in acute dichloroethane poisoning].

作者信息

Akimov G A, Buchko V M, Kolesnichenko I P

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1978;78(5):687-92.

PMID:665065
Abstract

The paper deals with a study of the nervous system in 121 patients with acute poisening with dichlorethane. Among the studied contingent there were 110 males and 11 females. According to the severity of the intoxication the patients were divided into 3 groups: mild--23 cases, moderate--11 cases, severe--87 cases. The following 6 neurological syndromes were distinguished: comatose, convulsive, atactic, extrapyramidal, psychotic and asthenic with vegetative-vascular insufficiency. Morphological studies detected the following: congestion plethora, vascular dystonia, microfoci hemorrhages, acute swelling of the nervous cells with signs of chromatolyses, shrunk cells, severe and ischemic change of the nervous cells. The treatment consisted in an accelerated elimination of dichlorethane from the organism and symptomatic therapy. The results of these studies demonstrated that in poisoning with dichlorethane there were diffuse, mainly dystrophic changes in the cells of the brain and spinal cord, which clinically may be expressed by symptoms of a lesion of many systems and may be qualified as toxic encephalomyelopathy.

摘要

本文对121例二氯乙烷急性中毒患者的神经系统进行了研究。在研究对象中,男性110例,女性11例。根据中毒严重程度,患者分为3组:轻度23例,中度11例,重度87例。区分出以下6种神经综合征:昏迷、惊厥、共济失调、锥体外系、精神病性和伴有植物神经血管功能不全的虚弱型。形态学研究发现:充血、血管张力障碍、微灶性出血、神经细胞急性肿胀伴染色质溶解迹象、细胞萎缩、神经细胞严重缺血性改变。治疗包括加速二氯乙烷从体内清除及对症治疗。这些研究结果表明,二氯乙烷中毒时脑和脊髓细胞存在弥漫性、主要是营养不良性改变,临床上可能表现为多个系统受损的症状,可诊断为中毒性脑脊髓病。

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