Blythe T H, Hall R C, Hughes I E
J Pharm Pharmacol. 1976 Jan;28(1):53-7. doi: 10.1111/j.2042-7158.1976.tb04023.x.
Guanethidine treatment of rate (30 mg kg(-1), i.p. daily for 6 weeks) produced a profound reduction in the catecholamine present (as indicated by fluorescence histochemistry and catecholamine determinations) in tissues taken from the cardiovascular system, but there was evidence of the return of catecholamines within 8 weeks. While these changes are consistent with a sympathectomy, the unaltered pressor responses to physostigmine (100 mug kg(-1), i.v.) and to carotid occlusion indicate an unimpaired functional capacity of noradrenergic nerves supplying the cardiovascular system. Although part of the response may be attributed to the unaffected adrenal medulla enhanced by the presence of considerable supersensitivity as shown to exogenous noradrenaline, there would appear to be a dissociation between the results obtained from physical and functional tests of the sympathectomy induced by guanethidine.
胍乙啶治疗大鼠（30毫克/千克，腹腔注射，每日一次，共6周）使取自心血管系统的组织中儿茶酚胺含量显著降低（荧光组织化学和儿茶酚胺测定表明），但有证据显示8周内儿茶酚胺会恢复。虽然这些变化与交感神经切除术一致，但对毒扁豆碱（100微克/千克，静脉注射）和颈动脉闭塞的升压反应未改变，表明供应心血管系统的去甲肾上腺素能神经的功能能力未受损。尽管部分反应可能归因于未受影响的肾上腺髓质因对外源性去甲肾上腺素表现出相当高的超敏反应而增强，但胍乙啶诱导的交感神经切除术的物理和功能测试结果之间似乎存在脱节。
