Klapdor R
Acta Hepatogastroenterol (Stuttg). 1978 Jun;25(3):193-202.
The distribution and excretion of i.v. injected c14-glycocholate (n = 8) and c14-cholate (n = 5) was measured in the serum, duodenal juice and urine in 13 patients in order to examine the possibilities to reporduce the measured data by a multi-compartmental analysis. The results demonstrate that a 3-exponential fitting and therefore a 3-compartmental model represents at present the most appropiate compartmental model for analyzing the distribition and excretion kinetics of the injected bile acids by mathematical procedures. In extending the previously described 2-compartmental model it encloses the 3-compartments plasma, liver and extrahepatoplasmatic space and allows a precise calculation of important physiological parameters, for example of the hepatic (V1/V2-clearance) and extrahepatoplasmatic (V1/V3-clearance) clearance, the biliary excretion and the distribution between the 3 compartments.
为了检验通过多室分析重现测量数据的可能性，对13例患者静脉注射¹⁴C - 甘氨胆酸盐（n = 8）和¹⁴C - 胆酸盐（n = 5）后，在其血清、十二指肠液和尿液中进行了分布和排泄测量。结果表明，三指数拟合以及由此得出的三室模型目前是通过数学方法分析注射胆汁酸的分布和排泄动力学最合适的室模型。在扩展先前描述的两室模型时，它涵盖了血浆、肝脏和肝外质空间这三个室，并允许精确计算重要的生理参数，例如肝脏（V1/V2清除率）和肝外质（V1/V3清除率）的清除率、胆汁排泄以及三个室之间的分布情况。
